|
KMID : 1140920190430010081
|
|
Annals of Rehabilitation Medicine
2019 Volume.43 No. 1 p.81 ~ p.86
|
|
|
Diagnostic Significance of Fibrin Degradation Products and D-Dimer in Patients With Breast Cancer-Related Lymphedema
|
|
Ryu Sang-Hyeong
Min Sang-Won
Kim Jae-Ho
Jeong Ho-Joong
Kim Ghi-Chan
Kim Dong-Kyu
Sim Young-Joo
|
|
|
Abstract
|
|
|
Objective: To find out whether levels of fibrin degradation products (FDP) and D-dimer are increased in breast cancer-related lymphedema (BCRL) as in many vascular diseases. FDP and D-dimer have been used in blood tests to help differentiate deep vein thrombosis in the diagnosis of lymphedema. Levels of FDP and D-dimer are often elevated in patients with BCRL.
Methods: Patients with BCRL (group I), non-lymphedema after breast cancer treatment (group II), and deep venous thrombosis (group III) from January 2012 to December 2016 were enrolled. Levels of FDP and D-dimer were measured in all groups and compared among groups.
Results: Mean values of FDP and D-dimer of group I were 5.614±12.387 and 1.179±2.408 μg/μL, respectively. These were significantly higher than their upper normal limits set in our institution. Levels of FDP or D-dimer were not significantly different between group I and group II. However, values of FDP and D-dimer in group III were significantly higher than those in group I.
Conclusion: Values of FDP and D-dimer were much higher in patients with thrombotic disease than those in patients with lymphedema. Thus, FDP and D-dimer can be used to differentiate between DVT and lymphedema. However, elevated levels of FDP or D-dimer cannot indicate the occurrence of lymphedema.
|
|
|
KEYWORD
|
|
|
Breast cancer related lymphedema, Fibrin degradation products, D-dimer, Deep vein thrombosis
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|